Transmitter-Gated Channels
نویسندگان
چکیده
منابع مشابه
How to Force Conformity on Transmitter-Gated Channels
Neurotransmitter-gated ion channels (LGIC) trans-duce a presynaptic event (release of transmitter) into a postsynaptic event (opening of channels). Given the vagaries of life for a synapse—the quantal content, the number of transmitter molecules in a vesicle, the exact release site, the statistics of transmitter binding, noise in the postsynaptic cell, and so forth—it would seem to be advantage...
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Neurons communicate through the exocytotic release of transmitters from presynaptic axon terminals and the ensuing activation of postsynaptic receptors. Instantaneous responses of postsynaptic cells to released neurotransmitters are mediated by ligand-gated ion channels, whereas G protein-coupled receptors mediate rather delayed effects. Moreover, the actions of ionotropic receptors are transie...
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The inhibitory neurotransmitter, GABA, activates a variety of receptors in all areas of the CNS. Two major subtypes of GABA receptors are well known: (1) GABAA receptors are ligand-gated Cl- channels that consist of a heteromeric mixture of protein subunits forming a pentameric structure, and (2) GABAB receptors couple to Ca2+ and K+ channels via G proteins and second messengers. Here, Graham J...
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Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
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Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2007
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0707203